Copio y pego de gbatemp
Want the build of Desmume that includes hi-res? Go nuts:

32-bit build: http://shikaver01.webcrow.jp/desmume...14-03-29-0.zip

64-bit build: http://mudlord.info/temp/DeSmuME_VS2010_x64_release.rar

However, SoftRasterizer is the best option to use at the moment. OpenGL is currently semi-broken with this and seems to only work with some games.

To enable Hi-Res:
1. Start Desmume
2. Go to Config -> High Resolution 3D Renderer, then choose from X2, X3, or X4, you can play with the other settings to your liking
3. ???
4. Profit!
El resultado es brillante, acabo de probarlo y se ve de novela.